abstract：INTRODUCTION:While guidelines for detection of silent myocardial and lower limb ischemia are established, data on screening asymptomatic carotid lesions remain scarce. However, such screening would be costly. Since the prevalence of diabetes increases constantly, it is necessary to keep screening costs low by setting u...

journal_title：Diabetes & metabolism

authors： Duval M,Altman JJ

更新日期：2006-12-01 00:00:00

abstract：:Optimal glycaemic control is necessary to prevent diabetes-related complications. An intensive treatment, which could mimic physiological insulin secretion, would be the best one. However subcutaneous insulin treatment is not physiologic and represents a heavy burden for patients with type 1 and type 2 diabetes mellit...

journal_title：Diabetes & metabolism

authors： Lassmann-Vague V,Raccah D

更新日期：2006-12-01 00:00:00

abstract：AIMS:To assess the prevalence and severity of bone disease in type 1 diabetic patients and to determine serum markers of bone remodeling as well as their relationship with bone mineral density (BMD). METHODS:BMD [by dual energy x-ray absorptiometry (DXA)] and serum markers of bone remodeling [osteocalcin, c-terminal t...

journal_title：Diabetes & metabolism

authors： Alexopoulou O,Jamart J,Devogelaer JP,Brichard S,de Nayer P,Buysschaert M

更新日期：2006-11-01 00:00:00

abstract：:There are few studies on the effects of postprandial hyperglycaemia, and usually it is assumed that its effects are the same as those of post-glucose-load hyperglycaemia, following a standard 75 g oral glucose tolerance test. There is some evidence from a study with blood drawn following ingestion of a standardised "d...

journal_title：Diabetes & metabolism

authors： Balkau B,Eschwège E

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Granulocytes from healthy subjects and from patients suffering from diabetes mellitus present differences in reactivity to stimulation with cyclic nucleotide-elevating agents. The production of reactive oxygen species (ROS) is inhibited in cells from non-diabetic subjects following such stimulation, but acti...

journal_title：Diabetes & metabolism

authors： Nogueira-Machado JA,Lima e Silva FC,Cunha EP,Calsolari MR,Costa DC,Perilo CS,Horta BC,Ferreira IC,Chaves MM

更新日期：2006-09-01 00:00:00

abstract：:The metabolic syndrome (MS) describes a cluster of metabolic disturbances including type 2 diabetes and/or insulin resistance, hypertension, dyslipidemia and obesity, which predict a high risk of cardiovascular disorders. The associated hyperinsulinemia and hyperleptinemia may contribute to the cardiovascular risk. Ho...

journal_title：Diabetes & metabolism

authors： Bonin-Guillaume S,Herrmann FR,Boillat D,Szanto I,Michel JP,Rohner-Jeanrenaud F,Vischer UM

更新日期：2006-06-01 00:00:00

abstract：:The CGMS (Continuous Glucose Monitoring System) is a portable device allowing continuous measuring of glucose. It provides recordings of at least 72 h, during which 288 measures/day are performed. Results are visualised in the form of a set of curves, illustrating the variations in blood glucose levels over time. The ...

journal_title：Diabetes & metabolism

authors： Melki V,Ayon F,Fernandez M,Hanaire-Broutin H

更新日期：2006-04-01 00:00:00

abstract：:Postprandial hyperglycaemia is a phenomenon often neglected by patients as well as doctors. While patients only voluntarily measure morning and preprandial capillary glycaemia, physicians do not encourage the measurement of anything further. The specific role of postprandial hyperglycaemia in the determination of late...

journal_title：Diabetes & metabolism

authors： Slama G,Elgrably F,Sola A,Mbemba J,Larger E

更新日期：2006-04-01 00:00:00

abstract：AIM:To investigate the locus of control in patients with type 2 diabetes followed by systemic group education (Group Care) and traditional one-to-one care. METHODS:In a post-hoc analysis, two questionnaires were administered to 56 patients who had been followed for 5-7 years by Group Care and 51 controls followed by i...

journal_title：Diabetes & metabolism

authors： Trento M,Passera P,Miselli V,Bajardi M,Borgo E,Tomelini M,Tomalino M,Cavallo F,Porta M

更新日期：2006-02-01 00:00:00

abstract：:Prevalence of diabetes is increasing worldwide in epidemic proportions. Its appropriate clinical management requires a careful etiological diagnosis. Laminopathies recently emerged as clinically heterogeneous genetic disorders due to mutations in lamins or lamin-associated proteins, which are components of the nuclear...

journal_title：Diabetes & metabolism

authors： Donadille B,Lascols O,Capeau J,Vigouroux C

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:NEUROD1 encodes a transcription factor expressed in the endocrine pancreas, and involved in beta-cell development, function and mechanisms of apoptosis. In this study, we investigated the association of a frequent polymorphism in exon 2 of NEUROD1 (G > A; Ala45Thr) with Type 1 diabetes in Brazilian subjects....

journal_title：Diabetes & metabolism

authors： Oliveira CS,Hauache OM,Vieira JG,Maciel RM,Sjöroos M,Canani LH,Velho G,Gross JL,Reis AF

更新日期：2005-12-01 00:00:00

abstract：:The "Société Française de Gériatrie et Gérontologie" (SFGG) and "Association de Langue Française pour l'Etude du Diabète et des Maladies Métaboliques" (ALFEDIAM) have decided to join their efforts in actions to improve the management and treatment of the elderly diabetic patients. New knowledge brought by the fundamen...

journal_title：Diabetes & metabolism

authors： Tréton J

更新日期：2005-12-01 00:00:00

abstract：:Hypertension is a major vascular risk factor in the elderly diabetic. The benefit of proper management is well recognized, even if treatment has no influence on overall mortality or might even tend to increase it in very elderly subjects. Globally, the efficacy of the major classes of antihypertensive drugs, diuretics...

journal_title：Diabetes & metabolism

authors： Blicklé JF

更新日期：2005-12-01 00:00:00

abstract：AIM:To study the foveal avascular zone (FAZ) of the central retina in diabetic patients with retinopathy having undergone metabolic evaluation. METHODS:One hundred and ten digital fluorescein angiograms were chosen from our digital image bank after cross matching diabetic patient lists of the ophthalmology and endocri...

journal_title：Diabetes & metabolism

authors： Conrath J,Giorgi R,Ridings B,Raccah D

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of a patient education program on diabetes control. METHODS:A pre-test post-test pre experimental study was performed with 87 insulin treated diabetic patients followed in the chronic disease unit of Kelibia district (Nabeul, Tunisia). Subjects received education in 6 monthly sess...

journal_title：Diabetes & metabolism

authors： Jenhani M,Gaha K,Nabouli R,Ghedira A,Ben Abdelaziz A

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that HbA1c is an important predictor of the glycometabolic state of patients admitted for acute myocardial infarction (AMI). OBJECTIVE:We aimed at comparing the results of HbA1c concentrations obtained by 2 different methods in patients with AMI. RESEARCH DESIGN AND METHODS:In a firs...

journal_title：Diabetes & metabolism

authors： Hadjadj S,Duengler F,Barriere M,Mauco G,Coisne D,Warnier F,Sosner P,Torremocha F,Herpin D,Marechaud R

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:In France, diabetic subjects were not allowed to dive. The principal risk is hypoglycemia during immersion. However scuba diving is allowed in many countries. To follow blood glucose changes, food intake and insulin adjustments in type 1 diabetic patients when diving, and to propose specific guidelines for su...

journal_title：Diabetes & metabolism

authors： Lormeau B,Sola A,Tabah A,Chiheb S,Dufaitre L,Thurninger O,Bresson R,Lormeau C,Attali JR,Valensi P

更新日期：2005-04-01 00:00:00

abstract：:Many studies have demonstrated the metabolic efficacy of continuous subcutaneous insulin infusion (CSII) and particularly a reduction of glycaemic fluctuations in type 1 diabetic patients. Despite this benefit, many patients decide to discontinue the use of CSII. To determine the factors related to discontinuation of ...

journal_title：Diabetes & metabolism

authors： Ronsin O,Jannot-Lamotte MF,Vague P,Lassman-Vague V

更新日期：2005-02-01 00:00:00

abstract：:A major aim of glucose-lowering therapy in people with diabetes is to delay or prevent the late-developing complications of diabetes that threaten the quality and duration of life. While intensive interventions to control hyperglycaemia may impair well-being to some extent, the balance of quality of life is usually hi...

journal_title：Diabetes & metabolism

authors： Consoli A,Gomis R,Halimi S,Home PD,Mehnert H,Strojek K,Van Gaal LF

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to investigate insulin secretion, insulin-receptor binding and peripheral insulin sensitivity in subjects with different degrees of obesity. METHODS:36 obese subjects with normal glucose tolerance and different degrees of obesity and 40 healthy normal-weight subjects partici...

journal_title：Diabetes & metabolism

authors： Borissova AM,Tankova TI,Koev DJ

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:Regular physical activity (PA) in young needs to be promoted to prevent obesity and subsequent diabetes. Influences of parental PA on adolescents' activity level have been studied with discordant results and the effect of socioeconomic status (SES) on these relationships is not clarified. METHODS:Cross-sect...

journal_title：Diabetes & metabolism

authors： Wagner A,Klein-Platat C,Arveiler D,Haan MC,Schlienger JL,Simon C

更新日期：2004-09-01 00:00:00

abstract：:Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia. A mod...

journal_title：Diabetes & metabolism

authors： Morbois-Trabut L,Maillot F,De Widerspach-Thor A,Lamisse F,Couet C

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...

journal_title：Diabetes & metabolism

authors： Zouari Bouassida K,Chouchane L,Jellouli K,Chérif S,Haddad S,Gabbouj S,Danguir J

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:End-stage renal disease (ESRD) requiring renal replacement therapy (RRT) is a late complication of type 2 diabetes. The correlation between pre-ESRD medical care and outcome has been rarely studied in France. METHODS:Community-based study of case-incIdent ESRD patients. Medical care practices were described ...

journal_title：Diabetes & metabolism

authors： Frimat L,Loos-Ayav C,Panescu V,Cordebar N,Briançon S,Kessler M

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To determine the utility of the continuous glucose monitoring system (CGMS) as an outpatient procedure to improve management of diabetes in adolescents. RESEARCH DESIGN AND METHODS:Twelve adolescents (mean age: 16.2 +/- 3 years) with poorly controlled type 1 diabetes (HbA(1c) > 8%) were included in this tria...

journal_title：Diabetes & metabolism

authors： Schaepelynck-Bélicar P,Vague P,Simonin G,Lassmann-Vague V

更新日期：2003-12-01 00:00:00

abstract：CONTEXT:In 2001 the "National Cholesterol and Education Program Expert Panel" gave a clinical definition of the metabolic syndrome. The frequency of this syndrome at baseline and its incidence and persistence at three years is studied in a French population. SUBJECTS:2109 men and 2184 women from the D.E.S.I.R. longitu...

journal_title：Diabetes & metabolism

authors： Balkau B,Vernay M,Mhamdi L,Novak M,Arondel D,Vol S,Tichet J,Eschwège E,D.E.S.I.R. Study Group.

更新日期：2003-11-01 00:00:00

abstract：:Type 2 diabetes is characterised by insulin resistance in association with clustering of atherothrombotic risk factors (dysglycaemia, hyperinsulinaemia, hypertension, raised triglyceride, low HDL cholesterol and increased levels of plasminogen activator inhibitor-1 (PAI-1) and clotting factor VII). There is a 3-5 fold...

journal_title：Diabetes & metabolism

authors： Grant PJ

更新日期：2003-09-01 00:00:00

abstract：:The timely series of state-of-the-art reviews contained within this supplement provide a valuable overview of the current state of diabetes care, and the pharmacological interventions we have available. Our experts agree that one of the most important lessons to emerge recently concerns the magnitude of the malign inf...

journal_title：Diabetes & metabolism

authors： Standl E

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:The aim of this retrospective study was to identify key factors favoring weight regain. METHODS:Therefore, prognostic factors for weight loss and regain have been retrieved and identified among 186 obese patients (40 +/- 2 y and 34 +/- 0.3 kg/m(2)) through the use of a simple questionnaire which considered p...

journal_title：Diabetes & metabolism

authors： Ybarra J,de Stefano M,Kammer A,de Tonnac N,Lehmann T,Golay A

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVES:To test the hypothesis that smokers have a higher frequency of the metabolic syndrome, and a syndrome with different characteristics than non-smokers. MATERIAL AND METHODS:The 2,569 men and 2,637 women included in the D.E.S.I.R. study, aged 30-64 years, volunteers from ten French Social Security Health Exam...

journal_title：Diabetes & metabolism

authors： Geslain-Biquez C,Vol S,Tichet J,Caradec A,D'Hour A,Balkau B,D.E.S.I.R. Study Group.

更新日期：2003-06-01 00:00:00

abstract：:Diabetic retinopathy rarely occurs before puberty and is never proliferative in prepubescent children. On the opposite, puberty and adolescence are high-risk periods for diabetic retinopathy progression, and call for strict ophthalmologic monitoring. The period between 16 and 18 years of age is particularly critical. ...

journal_title：Diabetes & metabolism

authors： Ben Mehidi A,Massin P,Guyot-Argenton C,Erginay A,Guillausseau PJ,Gaudric A

更新日期：2003-06-01 00:00:00

abstract：:Self-monitoring of blood glucose started only fifty years ago. Until then metabolic control was evaluated by means of qualitative urinary blood measure often of poor reliability. Reagent strips were the first semi quantitative tests to monitor blood glucose, and in the late seventies meters were launched on the market...

journal_title：Diabetes & metabolism

authors： Dufaitre-Patouraux L,Vague P,Lassmann-Vague V

更新日期：2003-04-01 00:00:00

abstract：:Insulin exerts its biological effects through a plasma membrane receptor that possesses a tyrosine-kinase activity. This tyrosine-kinase activity depends on the autophosphorylation of the receptor on tyrosine residues and on its dephosphorylation by protein tyrosine-phosphatases. The discovery of pharmacological agent...

journal_title：Diabetes & metabolism

authors： Issad T,Boute N,Boubekeur S,Lacasa D,Pernet K

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:The aim of the present study is to evaluate pregnancy outcomes in a cohort of Caucasian pregnant women in relation to their body mass index and glucose tolerance status; the role of central fat distribution, as indicated by waist-to-hip circumference ratio, was also considered. METHODS:Seven hundred women w...

journal_title：Diabetes & metabolism

authors： Bo S,Menato G,Signorile A,Bardelli C,Lezo A,Gallo ML,Gambino R,Cassader M,Massobrio M,Pagano G

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between CRP levels and the components of MS in normal glucose tolerant (NGT), impaired glucose tolerant (IGT), and Type 2 diabetic subjects. MATERIAL AND METHODS:A based cross-sectional population study was performed. Eligible subjects, men and non-pregnant women, 30 to 64 year ...

journal_title：Diabetes & metabolism

authors： Guerrero-Romero F,Rodríguez-Morán M

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Although the management of diabetes mellitus varies according to non medical factors, the influence of socioprofessional category has been not fully studied. This study compared the management of type 2 diabetes mellitus in craftsmen or tradesmen with professionals categories. METHODS:All claims to the Fren...

journal_title：Diabetes & metabolism

authors： Auleley GR,Dematons MN,Berchery P,Raynal-Minville F,Suarez F,Heuls-Bernin B,Blum-Boisgard C

更新日期：2002-12-01 00:00:00

abstract：:Insulin secretion from the beta-cells in the islets of Langerhans is mainly regulated by glucose entry via its transporter. The intracellular glucose metabolism induces a rise in ATP/ADP ratio which increases the degree of closure of ATP-sensitive potassium channels (K(ATP) channels), inducing a higher intracellular K...

journal_title：Diabetes & metabolism

authors： Bataille D

更新日期：2002-12-01 00:00:00

abstract：:The presence of thioredoxin peroxidase (TPx), also known as thiol specific antioxidant (TSA), was investigated in neonatal and adult rat islets, and in the beta-cell line HIT-T15. Western blotting of extracts from neonatal and adult pancreatic islets and from the tumoral cell line HIT-T15 revealed the presence of a 25...

journal_title：Diabetes & metabolism

authors： Boschero AC,Stoppiglia LF,Collares-Buzato CB,Bosqueiro JR,Delghingaro-Augusto V,Leite A,Carvalho CP,Netto LE,Carneiro EM

更新日期：2002-12-01 00:00:00

abstract：:Remittent isolated palsy of peripheral or of upper cranial nerves in diabetic patients is well documented, but paralysis of a lower cranial nerve or an isolated branch of any cranial nerve has rarely been reported. In the case described, besides temporary hypoglossal and facial nerve palsies previously, unilateral tem...

journal_title：Diabetes & metabolism

authors： Semiz S,Fişenk F,Akçurin S,Bircan I

更新日期：2002-11-01 00:00:00

abstract：:The project to finalize a 'closed loop' insulin delivery according to blood glucose level, i.e. an implanted artificial beta cell, is born from the development of the first miniaturized portable insulin pumps during the 1970s. Continuous improvements in micro-electronics, as well as in the development of biomaterials ...

journal_title：Diabetes & metabolism

authors： Renard E,Costalat G,Bringer J

更新日期：2002-09-01 00:00:00